VDR is a gene which encodes for a vitamin D receptor protein. This protein regulates calcium absorption as well as bone growth. A variant of the gene (rs2228570 FokI polymorphism) is associated with a reduced bone mineral density among prepubescent girls of white background.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern as well as the temporal on-and-off occupancy of VDRE between the two components. It is also controlled by chromosomal locations and binding preferences for specific hormones. Microarray studies in human cells show that more than 100 genes contain VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository of data and documents relevant to business, legal transactions or proceedings that are restricted in viewing, downloading or printing. It is accessed via a central server and an extranet connection which is an Internet connection that has restricted access, to offer restricted more access to log-in for specific time periods during which users are able to view the data and documents.
Investment bankers and companies involved in mergers and acquisitions are among the most frequent users of a VDR. They require to communicate information in a clear manner with potential investors or buyers. Due diligence processes can also require a large amount of data. Life science companies also utilize VDRs for everything from clinical trial data to HIPAA documentation for compliance.
